Writing about a wrongly accused character with a mystery to solve

Victoria Lynn Schmidt has summarised the plot of The Fugitive as:

Wrongly convicted of murdering his wife, Dr. Richard Kimble escapes from a prison bus and tries to find out why she was killed and who the murderer really was. He is fleeing a U.S. marshal while pursuing the truth.

Write a story about a character who is suspected of (and possibly punished for) something and then becomes motivated to find out what really happened.